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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

2.室内类比赛项目
排在第八位的是29岁的中国模特刘雯,她的收入为650万美元,她是榜单上唯一一位亚洲模特,这也反映了缺少多样性的问题依然影响着模特界。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

His footballing rival Lionel Messi - who the 31-year-old beat to be crowned the World Player of the Year in January - was second on the list, taking home pound 56 million in 2015/16.
It can free up bartenders so they can make more drinks when it's busy.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Gisele, 37, came in second place, having earned $17.5 million, marking the first year she has not headed up the line-up since 2002.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

尽管Facebook在中国被屏蔽,腾讯还是将微信同Facebook连接起来,这意味着中国以外的用户可以同时使用微信和世界上最流行的社交网络。在印尼、泰国和菲律宾等东南亚国家,这对腾讯是有好处的,因为这些国家拥有很多Facebook用户。腾讯针对这三个市场都推出了各自语言版本的微信。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 市场调整助建陶行业发展
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Gary Oldman on blistering form as Winston Churchill.
出口复苏可能在一定程度上化解人们对于新兴市场国家的悲观看法。在本世纪初的那些年,许多新兴市场国家曾把出口强劲增长作为经济快速发展的跳板,后来出口由盛转衰了。
Tracey and Viv Williams, a British couple, dressed as the green cartoon ogres from Shrek at their wedding held recently. Tracy, 33, made a lovely Princess Fion
Have some respect for those who are promoting your work and hosting you to remove the gum before the interview begins.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

6. Gene therapy comes good.
Whedon had always loved the seemingly separate ideas of sci-fi and westerns, and through The Killer Angels, he saw a way to combine them. "I wanted to play with that classic notion of the frontier," he said. "Not the people who made history, but the people history stepped on—the people for whom every act is the creation of civilization." And Whedon decided to set the frontier on a spaceship: a ship named Serenity.
The Glory of Tang Dynasty
哈维?C?曼斯菲尔德是哈佛大学最直言不讳的保守派教授,他也是《刚毅》一书的作者。曼斯菲尔德告诉《卫报》,他对这个决定存有质疑。“人们对无礼冒犯的界定已经被放大歪曲,我不再相信那些坚持政治正确的执法者做出的不公判决。”

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

他的投篮许多次都是只打中篮筐的前沿儿。而一些三分投篮甚至投出了三不沾。许多本应是扣篮的球最终他只选择了上篮,当然了,这是相比在若干年前没有任何伤病的他而言的。而最残酷的是,其中一次投篮,科比甚至把球嵌在了篮筐与篮板之间。最终还是对方的球员把球拿了下来。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

单词galaxy 联想记忆:

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Consider this: Will the experience enhance your knowledge and play to your strengths? Will it introduce you to new concepts and new people? (All great reasons to say yes!) Will it require you to develop new techniques for managing your team or working with more experienced people? Embrace this challenge and get out of your comfort zone.
Originally intended for the opening credits of Tomorrow Never Dies, and then for some reason relegated to the closing credits, K.D. Lang's "Surrender" is silken and cool. The horn sections are sassy and powerful. It's one of the best James Bond theme songs, and it's not even officially a James Bond theme song. And it's a heck of a lot better than the official theme the movie finally got.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

At its Worldwide Developer Conference in June, Mr Cook was mobbed by app makers who asked him to pose for selfies. By October’s iPad launch, he was even cracking jokes at his own expense. Clad in his habitual but unglamorous uniform of black untucked shirt and jeans, he said that Apple Watch had been well received by “people who know a lot about fashion and style — even more than I do”, pointing a knowing finger at the chuckling audience.
She said: 'Bobbi's like a little Beyonce, a little madam really.'

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Hailed as one of the greatest films of all time, Taxi Driver tells the story of a depressed ex-Marine who attempts to assassinate a senator after being rejected by a woman he admires. While the titular taxi driver, Travis Bickle, lives a chaotic life filled with drug dealers and prostitutes, his story was never meant to be an unrealistic fantasy. Rather, it meant to expose the very real warning signs of a would-be gunman.
在婴儿出生前治疗出生缺陷

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Stop me if you've heard this one before: An untested social media company with no revenue gets a mind-blowing offer. Against all advice, the cocky, twentysomething CEO refuses to sell. Meanwhile, competitors come out of the woodwork with lawsuits claiming their ideas were ripped off.
adj. 自信的,有信心的,有把握的
一项由中国职业介绍机构智联招聘(Zhaopin)对1.15万名员工开展的调查发现,2016年底有50.9%的员工没有拿到年终奖。还有9.6%的员工则被告知年终奖会推迟至春节假期后发放。
影片可能太过非主流,不具有获得大奖的影响力。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Demagogues are the Achilles heel of democracy.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 深圳加快建立多主体住房供应体系
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

历届“邦女郎”性感比拼
在完成作业不久之后,孙轶萧就听到外面嘈杂的响声。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

On Saturday night they sang Stars from Les Miserables, the song performed the character Javert in the long-running musical.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 深化市场化改革释放经济增长潜力
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

The PPI has been negative for 44 consecutive months, reflecting excess supply of housing materials and raw materials, and overcapacity in heavy industry.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

蒂莫西·哈顿(Timothy Hutton)的小金人对归属问题做出了最好的答复,哈顿曾在影片《凡夫俗子》中表现十分优异,并成为奥斯卡金像奖最年轻的最佳配角奖得主。在数年前的一次聚会中,他的姐姐突然从冰箱里拿出小金人,和啤酒一起随机放在某处,使宾客们能够碰巧在路上拿到它,从而提提神。显然,现在它还在那里。
从一个孩子的视角,讲述佛罗里达州一家汽车旅馆社区的生活。
6.凡事以人为先
A. O. Scott

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

最佳男歌手:杰森·阿尔丁
据信,宝能借入了大笔资金来购买万科的股票。现在,它已是万科最大的股东,持股比例为25%。
Do your homework. Read the assigned pages, and then some. Plug your topic into the Internet, grab another book at the library, and see what else you can learn about the subject.
保安负责监管烘焙坊一次能容纳多少蛋糕狂热者。当然,木兰烘焙坊并没有因为人多而怨气冲冲。烘焙坊把电视剧纪念品展览于多家分店的墙上,并引以为豪。现在,木兰烘焙坊以香蕉布丁而闻名,但他们的最初成功应该归功于凯莉·布拉德肖以及红天鹅绒纸杯蛋糕。
“我们会根据天气谨慎考虑投送的时间和地点,但这些都不会公开,”脱北者Park Sang-Hak说道,他曾经领导过一系列的气球投送运动。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

科学家表示,全球变暖加上强大的厄尔尼诺气候事件,令2015年成为自19世纪现代记录开始以来最热年份。科学家还警告,今年地球可能会更热。
Entrepreneurs are movers and shakers. They can’t afford to analyze every detail or they’d never get anywhere. There is no place for procrastination in a startup. It’s a 24/7, no-vacation-or-sick-days kind of job that demands constant forward momentum. Make a brief assessment at every step and move on it. Trust your instincts.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Estimates for the size of the industry vary but Goldman Sachs figures suggest that sector loans grew from Rmb6bn to Rmb83bn between 2012 and 2014.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

administration

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

SplashData has revealed its list of the worst passwords of 2017, using data from more than 5 million passwords leaked this year – and, once again, ‘123456’ and ‘password’ top the list.
adj. 商业的
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
据Birinyi Associates的数据,今年迄今为止,各家公司已经宣布了376项股票回购计划,总额高达2,610亿美元。这个数字与2012年相比增长了近72%,但与回购创下纪录的2013年相比,略微有所回落。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

She emotes with some of Pink's husky attitude and some of Sia's theatrical so-over-it-ness, but she's a warmer singer than either, whether shrugging off a lover on the self-explanatory "IDGAF" or matching Miguel's intensity on the steamy "Lost in Your Light."
如果在“消极情感”和“社交抑制”两个维度得分均为10分或10分以上,那么你就是一个有D型人格特征的人。
根据两位了解相关计划的人士的说法,中国政府正在禁止中国旅游团体赴韩国旅游,这是对韩国拟部署美制萨德(Thaad)反导系统的最新报复手段。
We will continue to work to see that government functions are fully carried out in accordance with law.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Scott Brooks gets leeway as he learns his roster, and injuries continue to play too big a role. But I just can't fathom why this team is so much worse than the playoff team from a couple years back. The other piece is that it's unlikely the Wizards can conceivably be bad enough to get a top-five pick.
She said: 'Bobbi's like a little Beyonce, a little madam really.'

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

产品看起来并不太像一个鼻子,而是一个瓶子,装满了培养细菌的营养液体。但是给这个“鼻子”一个血液样本,让它嗅上一段时间,这个瓶子的斑点会改变颜色来表示它鉴别出的细菌种类。
[in'telidns]
007系列电影主题曲第八名:南希·辛纳查--《你只能活两次》
revis修正+ion→修正,校订本
除了编程和写作业,达洛伊西奥开始抽时间来阅读自然语言处理(natural language processing)方面的文章。他还学习了拉丁文和中文,并且对语言学理念产生了浓厚的兴趣,例如语法框架、语素解析,以及上世纪60年代语言学家理查德?蒙塔古(Richard Montague) 的理论。达洛伊西奥热情地说道,他是我最喜欢的语言学家,根据他的理论,自然语言可以被视作遵照一定句法写出的编程语言。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Leadership
distract
n. 部分,份,命运,分担的责任

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 房企资金趋紧暂难改
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

节目21 歌曲《幸福》,毛阿敏
2010年英文新年祝福邮件

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 聚焦:LED照明企业最新热点
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

In August, the holdings were to the tune of $80.4 billion while it stood at $79.7 billion in July.
An international medical journal's retraction of 107 research papers from China, many of them by clinical doctors, has reignited concerns over academic credibility in the country.
如果法国总统奥朗德在2012年上任后没有主动减薪30%,他的排名还能更靠前。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Consumer and producer prices are still either muted or in deflationary territory in China – but last month marked something of an uptick for each.
The report noted that 201 million people or 27 percent of Internet users were from rural areas, or a gap of 45.2 percent in the Internet penetration rate between urban and rural areas.
6. Now, like an addict who can't stop, Gross writes in his Tipping Point blog that QE will run to 2015. Earlier it seemed like the Bubble With No Name Yet should be renamed the Bernanke Bubble. But now, with Gross and Pimco's $2 trillion at stake here, maybe we should call it The Gross Bubble.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Will Trump trigger a trade war with China

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

珍妮弗 洛佩兹

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

St. Vincent “Digital Witness” (Loma Vista/Republic)
在过去的二十年里,几起校园中毒事件引发了群众对学生心理发展及帮助的争论和关注。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

皮肤辛苦的担任着包裹我们和保护我们整个身体的责任,因此它也成为了最容易被伤害的器官。当皮肤被烧伤或者被割破,你最快的选择是从身体其他部位移植一部分过来。然而,感谢斯坦福大学科学家的研究,一种能有效替代人体皮肤的材料,不久后将面世。
After weeks of rumors, Phil Jackson failed to move Carmelo Anthony and Derrick Rose, two players who absolutely should have been traded for the long-term benefit of the franchise.
lace
In June this year, a collaboration between universities and industry announced that it had discovered a huge reserve of helium gas in Tanzania, using a new exploration technique.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Brazil lost that 1950 final, 2-1, to Uruguay, a historic humiliation that still stings Brazilian fans today. Belmonte, 85, hopes he'll get to see his country regain its honor. "I hope Brazil will be able to win this time," he said. "This is our revenge. I want to go see our revenge."
扎实推进新型城镇化。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

指数:94.2
制度也可能失效。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

中国首先要把自己的事情办好,但关起门来也办不好自己的事情。所以我们的开放大门会越开越大。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

当前油价正在发生什么变化?在业内人士和严肃的投资者中间,对这个问题有两种不同的看法。2016年油价走势或许有助我们看清哪种观点是正确的。
智能皮带
她笔下的人物们觉得自己为了登上“美国梦”的山巅,经历了漫长的排队等候,但是上山的队伍放慢了速度,甚至停顿下来了。而那些移民、黑人和其他“外来者”似乎还在插队。
No. Football punditry is a mug’s game. Better to have the benefit of hindsight. There have been 20 previous World Cups. Of those, Brazil (five titles) and Germany (four), are regular contenders. Home advantage helps, with host nations winning the trophy six times. But next year’s festival of football is being held in Russia, which has the lowest-ranked team in the tournament.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

2013年排名:14
v. 构成,把 ...

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

中欧之间存在贸易摩擦,我们有经验去妥善解决。
与此同时,苹果正在引入昂贵的新组件,包括OLED显示屏,使手机正面成为一个连续屏幕。深度感应摄像头将提供“增强现实”新功能,并允许手机通过人脸识别(而不是指纹)解锁。
v. 决定,决心,确定,测定

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 家电行业首个七星服务标准出台
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

By 2020, annual box office sales are expected to reach 100 billion yuan, according to industry estimates.
When things do go wrong, Mr Cook takes swift and merciless action. In late 2012, after the premature launch of Apple’s flawed Maps app, he dismissed Scott Forstall, who led the creation of iOS and was a close ally of Jobs, and John Browett, the former Dixons chief who had led Apple retail for less than a year. The actions sent a message that Mr Cook will not tolerate underperformance or internal politics.
而或许更引人关注的问题是,雅虎究竟为何决定拿出3,000万美元来收购一款手机应用呢?诚然,Summly的文本精炼能力与新战略下的雅虎对移动设备的侧重不谋而合。伴随着以11亿美元对轻博客的收购,以及广受好评的新款天气应用的推出,Summly软件的加入见证了雅虎占领智能手机领域的坚定决心,以及为爱使手机的年轻消费者提供优质服务的不懈努力。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

“…was snervous she almost fainted.”
Snap, however, has sunk to about $15 after initially rallying from its IPO price of $17 in March, damping some expectation of further activity involving so-called decacorns, tech companies that have achieved valuations of $10bn or more through private funding.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

据《泰晤士报》高等教育星期四公布的最新排名,中国的两所大学--香港大学和澳门大学,跻身2016全球大学国际化水平前十名。
The official non-manufacturing PMI came in at 54.3 in October, down from a recent peak of 55.4 a month prior. A key sub-index for the services sector likewise fell 0.9 points from its September peak to 53.5. Even the construction industry appeared worse off, with a sub-index for the sector dropping 2.6 points to 58.5.
Last but not least, no matter what kind of personality you are, be positive and stay healthy!

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Paul was a pretty undersized guard back in high school, which is probably why he's developed such a "me against the world" mentality. CP3 is one of the grittiest and toughest players in the NBA, and he has to be because he sure isn't one of the biggest.
[?'?u?d]

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Its corporate customers value the school’s flexibility and ability to innovate. “We have developed a programme which is co-delivered with an experimental learning provider,” commented one client responding to the FT survey. “Iese has been a true partner in this process and our business has benefited with an energised and prepared executive bench.”
2. “Inside Out” (Pete Docter)
下面是今年最令人难忘的四个设计,包括参与塑造这些造型的一些艺术家们的评论。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

超八成中国留学生会在国外完成学业之后归国,而2016年我国留学生的数量达到了544500人。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

At least one model of the next iPhone is expected to feature image-capture technology that can sense depth, and track faces and expressions. A range of new emojis include monkeys and robots, whose animated expressions can mirror the iPhone user’s face as Apple battles for users’ attention with the likes of Facebook and Snapchat.
The best bosses understand that there must be a balance between the company or client’s needs and the needs of his or her employees. The best bosses are willing to listen and talk about any issues an employee may be having because they understand that a happy employee is a more productive employee。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

"It is a truly a global phenomenon in which people, due to lack of opportunities, have to leave their families behind to provide for them," said Pedro De Vasconcelos, IFAD policy advisor and author of the report.
comedy

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 住建部严控建材质量
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

The top obsession of 2010 was the much-anticipated iPhone, followed by actress Lindsay Lohan, the iPad, and the television shows "Glee" and "Jersey Shore".
凯莉·克莱森、蒂姆·麦格罗、泰勒·斯威夫特、凯莉·安德伍德、米兰达·兰伯特等人的现场表演high翻了米高梅大花园露天剧场。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

万分沮丧之下,他发明了可以允许自拍的东西:他称之为"伸缩杆"。因为智能手机还没发明出来,所以,连接在自拍杆末端的是一个微型相机。在杆的前端有一面小镜子,方便使用者调整他们在相机里的姿态。他在1983年为"伸缩杆"申请了专利。虽然自拍杆进行了大量生产出售,却属商业败笔——相片的质量比较差。另外,以前的研究表明,那时的女士会因自己有自拍的想法而感到尴尬。在2000年,自拍杆被韦恩·弗洛姆(Wayne Fromm)重新发明,那时,上田宏的"伸缩杆"专利期尚有三年。弗洛姆称他的自拍杆为"快捷豆荚"。他认为他才是当今自拍杆的发明者,甚至起诉其他自拍杆生产者。当被问到上田宏的自拍杆时,弗洛姆评论说它们是"先前的艺术"。
[i'nili]

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

进入2月以来,猛龙逐渐感到他们需要进行人员调整了:良好的开局已经被挥霍的差不多了,他们的防守不足以限制对手,他们在四号位有个巨大的漏洞,在凯尔-洛瑞即将成为自由球员之前,他们急迫的需要利用好他的巅峰期。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 9个超低能耗建筑项目获奖励
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

vt. 使成为可取,
12月工业利润下滑突显出中国工业面临的产能过剩和价格下跌的困扰,这加大了中国政府放松货币政策并扩大基础设施支出,以缓和经济放缓影响的压力。
刘非也是汉朝皇帝汉武帝(公元前141-97在位)的同父异母兄弟。
Employment growth exceeded projections.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Mr Karl added: “We would have likely had a record [year] even without El , but it pushed it way over the top.”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Anton, who works in the military, said: 'I thought the Beyonce routine was inappropriate when Steph first told me about it, but when I saw her on the stage doing it, it worked out quite well and everyone enjoyed it.'
Average age: 36 for English blended program
However, respondents also noted that social media has caused them to read fewer books, suffer from worse eyesight, sleep less and maintain less privacy, among other concerns.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 新木材法对我国木家具的影响
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖,同时还有Lana Del Rey,Lorde,The XX和Imanine Dragons等人提名。
《巴克斯托姆》(Backstrom),Fox,1月22日播出。去年,福克斯推出根据一部澳大利亚电视剧《法庭浪子》(Rake),由格雷格·金尼尔(Greg Kinnear)主演,讲述一个自毁律师的故事。那部剧没成功,但现在Fox又试着推出了一部根据瑞典系列小说改编的自毁侦探的故事,由《办公室》(The Office)男星雷恩·威尔森(Rainn Wilson)主演。这部剧由Fox的系列剧《识骨寻踪》(Bones)的编剧哈特·汉森(Hart Hanson)主创,但在试播集里,威尔森饰演的巴克斯托姆看上去更像豪斯医生(House),而不像《识骨寻踪》里的角色。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Against: There was no love from the New York nor LA critics.
这些各不相同的胡子是设计师弗朗西丝·汉农(Frances Hannon)设计的,在安德森的多部电影中(比如《青春年少》[Rushmore]和《水中生活》[The Life Aquatic With Steve Zissou]),她都为比尔·默里(Bill Murray)设计了面部毛发。这次,她让该片的很多演员留起胡子,供她修剪成任何想要的形状。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

默里留了满脸胡子,这样汉农就能修剪成附图中这种浓密的胡子。“比尔以前从没留过这种胡子,”汉农说,“加点新东西,挺可爱的。”

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 《北京市城乡规划条例》全文发布
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

这是英国影评人参与评选的娱乐性奖项,为在参展影片中表现最精彩的狗颁发纪念奖章。颁奖仪式于上周五(5月22日)在英国展馆举行。今年的金棕榈狗狗奖颁给了一只名叫幸运的狗,它是马耳他梗犬(Maltese terrier)与贵宾犬(Poodle)的混血品种。幸运出现在米古尔?戈麦斯(Miguel Gomes)时长6小时的巨作《一千零一夜》(Arabian Nights)中,在剧中叫做迪克西。幸运的奖品是一只玩具狗骨头,通过视频幸运发表了简短的获奖感言(汪)。但据法新社报道,在这大家其乐融融的时刻,一位法国记者认为在极具魅力的影展间隙举办这样的颁奖仪式真是“英国人愚蠢性格的无端干扰”。“在法国人看来,这有些奇怪,”他在报道中说。“英国人真是不可思议。”
Best Companies rank: 1
The average entrepreneur uses dozens of cloud-based software and apps. Zapier connects your online life and helps you build new functionality. The best part about Zapier is that you don’t have to be an API wizard to use it.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

然后,事情峰回路转。库迪斯和沃斯发现,荷兰贷款机构对于Seppenwolde的倒闭做出的反应截然不同。那些曾经贷款给Seppenwolde、但一毛钱也没损失的贷款机构变得越发悲观,要求所有新借款人都提供更多的“折幅”。而那些从未贷款给Seppenwolde、因而躲过一劫的贷款机构则根本没有提高要求。事实上,这些贷款机构可能还略略降低了对借款人的“折幅”要求,至少表明他们和过去一样乐观。
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
单词receptive 联想记忆:
Wages will finally accelerate after years of stagnation

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

5. Bank of America Corp.
如果上述情况都变成现实,休伯蒂估计苹果在中国智能手机市场上已跌至10%的份额将会提高三倍,达到近30%。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

With 10 guesses, an attacker would have a 39% chance of guessing Korean-speaking users' answers to the question "What is your city of birth?"
发展文化事业和文化产业。
The BFC's news has been met with support from people on social media, who have applauded the designers choosing to forgo the use of animal fur.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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Search giant Google has replaced iPhone makers Apple to be the world's most valuable company in the Brand Finance's Global 500 2017 report.
He also posted a picture of himself looking at a racially diverse group of children.

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